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Medicines During Pregnancy
Doctors usually tell women to avoid medicines during pregnancy, if possible, especially during the first 3 months. That is when a baby's organs form. But sometimes you have to take medicine to treat a health problem, such as high blood pressure or asthma.
So first your doctor or midwife will look at the risk. Is the risk of taking a medicine higher than the risk of not treating your illness? If you or your baby would face worse problems without treatment, then your doctor or midwife will prescribe medicine or recommend an over-the-counter one. He or she will also look at which medicine to give you. For example, some antibiotics are safe for pregnant women. And some are not.
What medicines can you take during pregnancy?
It can be hard to know if a medicine is safe for your baby. Most medicines are not studied in pregnant women. That's because researchers worry about how the medicines might affect the baby. But some medicines have been taken for so long by so many women that doctors have a good idea of how safe they are. Talk to your doctor or midwife before you take any medicines.
In general, doctors say it is usually safe to take:
- Acetaminophen (such as Tylenol) for fever and pain.
- Penicillin and some other antibiotics.
- HIV medicines.
- Some allergy medicines, including loratadine (such as Alavert and Claritin) and diphenhydramine (such as Benadryl).
- Some medicines for high blood pressure.
- Most asthma medicines.
- Some medicines for depression.
If you are planning a pregnancy, talk to your doctor or midwife about any medicines you take, even over-the-counter ones. Some of them may be safe to take while you're pregnant. But others may not be safe. Your doctor or midwife may have you stop taking a medicine or may switch you to another one. Some medicines that aren't safe in the first trimester may be safe to use later in the pregnancy.
What medicines should you avoid during pregnancy?
Some medicines are known to increase the chance of birth defects or other problems. But sometimes there's more risk for the mother and her baby if she stops taking a medicine (such as one that controls seizures) than if she keeps taking it. Talk to your doctor or midwife about any medicines you take if you are thinking about having a baby or if you are pregnant.
Some of the over-the-counter medicines that increase the chances of birth defects are:
- Bismuth subsalicylate (such as Pepto-Bismol).
- Phenylephrine or pseudoephedrine, which are decongestants. Avoid medicines with these ingredients during the first trimester.
- Cough and cold medicines that contain guaifenesin. Avoid medicines with this ingredient during the first trimester.
- Pain medicines like aspirin and ibuprofen (such as Advil and Motrin) and naproxen (such as Aleve). The risk of birth defects with these medicines is low.
Some of the prescription medicines that increase the chances of birth defects are:
- The acne medicine isotretinoin (such as Amnesteem and Claravis). This medicine is very likely to cause birth defects. It should not be taken by women who are pregnant or who may become pregnant.
- ACE inhibitors, such as benazepril and lisinopril. They lower blood pressure.
- Some medicines to control seizures, such as valproic acid.
- Some antibiotics, such as doxycycline and tetracycline.
- Methotrexate. It is sometimes used to treat arthritis.
- Warfarin (such as Coumadin). It helps prevent blood clots.
- Lithium. It is used to treat bipolar depression.
- Alprazolam (such as Xanax), diazepam (such as Valium), and some other medicines used to treat anxiety.
- Paroxetine (such as Paxil). This medicine is used to treat depression and other conditions.
Is it okay to take herbal supplements and vitamins?
Talk to your doctor or midwife about any herbal supplements that you take. Don't take any vitamins or herbal or other supplements unless you talk with your doctor or midwife first.
Women who are trying to get pregnant and those who are pregnant should take a multivitamin that has folic acid. Folic acid is most important before and in the first few weeks of pregnancy, because it prevents some birth defects. You can get folic acid in an over-the-counter multivitamin. Or you might get it in a multivitamin that your doctor or midwife prescribes. Talk to your doctor or midwife about which type of vitamin you should take. In some cases, doctors and midwives prescribe extra iron or extra folic acid.
Other Works Consulted
- Cunningham FG, et al. (2010). Teratology and medications that affect the fetus. In Williams Obstetrics, 23rd ed., pp. 312–333. New York: McGraw-Hill.
- U.S. Food and Drug Administration (2015). FDA Drug Safety Communication: FDA has reviewed possible risks of pain medicine use during pregnancy. U.S. Food and Drug Administration. http://www.fda.gov/Drugs/DrugSafety/ucm429117.htm. Accessed March 24, 2015.
- Yankowitz J (2008). Drugs in pregnancy. In RS Gibbs et al., eds., Danforth's Obstetrics and Gynecology, 10th ed., pp. 122–151. Philadelphia: Lippincott Williams and Wilkins.
Current as of: February 11, 2020
Author: Healthwise Staff
Sarah Marshall MD - Family Medicine
Kathleen Romito MD - Family Medicine
Adam Husney MD - Family Medicine
Elizabeth T. Russo MD - Internal Medicine
Kirtly Jones MD - Obstetrics and Gynecology
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